Sensorimotor cortex as a critical component of an 'extended' mirror neuron system: Does it solve the development, correspondence, and control problems in mirroring?

A core assumption of how humans understand and infer the intentions and beliefs of others is the existence of a functional self-other distinction. At least two neural systems have been proposed to manage such a critical distinction. One system, part of the classic motor system, is specialized for the preparation and execution of motor actions that are self realized and voluntary, while the other appears primarily involved in capturing and understanding the actions of non-self or others. The latter system, of which the mirror neuron system is part, is the canonical action 'resonance' system in the brain that has evolved to share many of the same circuits involved in motor control. Mirroring or 'shared circuit systems' are assumed to be involved in resonating, imitating, and/or simulating the actions of others. A number of researchers have proposed that shared representations of motor actions may form a foundational cornerstone for higher order social processes, such as motor learning, action understanding, imitation, perspective taking, understanding facial emotions, and empathy. However, mirroring systems that evolve from the classic motor system present at least three problems: a development, a correspondence, and a control problem. Developmentally, the question is how does a mirroring system arise? How do humans acquire the ability to simulate through mapping observed onto executed actions? Are mirror neurons innate and therefore genetically programmed? To what extent is learning necessary? In terms of the correspondence problem, the question is how does the observer agent know what the observed agent's resonance activation pattern is? How does the matching of motor activation patterns occur? Finally, in terms of the control problem, the issue is how to efficiently control a mirroring system when it is turned on automatically through observation? Or, as others have stated the problem more succinctly: "Why don't we imitate all the time?" In this review, we argue from an anatomical, physiological, modeling, and functional perspectives that a critical component of the human mirror neuron system is sensorimotor cortex. Not only are sensorimotor transformations necessary for computing the patterns of muscle activation and kinematics during action observation but they provide potential answers to the development, correspondence and control problems

The "True" Column Density Distribution in Star-Forming Molecular Clouds

We use the COMPLETE Survey's observations of the Perseus star-forming region to assess and intercompare three methods for measuring column density in molecular clouds: extinction mapping (NIR); thermal emission mapping (FIR); and mapping the intensity of CO isotopologues. The structures shown by all three tracers are morphologically similar, but important differences exist. Dust-based measures give similar, log-normal, distributions for the full Perseus region, once careful calibration corrections are made. We also compare dust- and gas-based column density distributions for physically-meaningful sub-regions of Perseus, and we find significant variations in the distributions for those regions. Even though we have used 12CO data to estimate excitation temperatures, and we have corrected for opacity, the 13CO maps seem unable to give column distributions that consistently resemble those from dust measures. We have edited out the effects of the shell around the B-star HD 278942. In that shell's interior and in the parts where it overlaps the molecular cloud, there appears to be a dearth of 13CO, likely due either to 13CO not yet having had time to form in this young structure, and/or destruction of 13CO in the molecular cloud. We conclude that the use of either dust or gas measures of column density without extreme attention to calibration and artifacts is more perilous than even experts might normally admit. And, the use of 13CO to trace total column density in detail, even after proper calibration, is unavoidably limited in utility due to threshold, depletion, and opacity effects. If one's main aim is to map column density, then dust extinction seems the best probe. Linear fits amongst column density tracers are given, quantifying the inherent uncertainties in using one tracer (when compared with others). [abridged]Comment: Accepted in ApJ. 13 pages, 6 color figures. It includes small changes to improve clarity. For a version with high-resolution figures see http://www.cfa.harvard.edu/COMPLETE/papers/Goodman_ColumnDensity.pd

A Systematic Review of The Potential Use of Neurofeedback in Patients with Schizophrenia.

Schizophrenia (SCZ) is a neurodevelopmental disorder characterized by positive symptoms (hallucinations and delusions), negative symptoms (anhedonia, social withdrawal) and marked cognitive deficits (memory, executive function, and attention). Current mainstays of treatment, including medications and psychotherapy, do not adequately address cognitive symptoms, which are essential for everyday functioning. However, recent advances in computational neurobiology have rekindled interest in neurofeedback (NF), a form of self-regulation or neuromodulation, in potentially alleviating cognitive symptoms in patients with SCZ. Therefore, we conducted a systematic review of the literature for NF studies in SCZ to identify lessons learned and to identify steps to move the field forward. Our findings reveal that NF studies to date consist mostly of case studies and small sample, single-group studies. Despite few randomized clinical trials, the results suggest that NF is feasible and that it leads to measurable changes in brain function. These findings indicate early proof-of-concept data that needs to be followed up by larger, randomized clinical trials, testing the efficacy of NF compared to well thought out placebos. We hope that such an undertaking by the field will lead to innovative solutions that address refractory symptoms and improve everyday functioning in patients with SCZ

The COMPLETE Survey of Outflows in Perseus

We present a study on the impact of molecular outflows in the Perseus molecular cloud complex using the COMPLETE survey large-scale 12CO(1-0) and 13CO(1-0) maps. We used three-dimensional isosurface models generated in RA-DEC-Velocity space to visualize the maps. This rendering of the molecular line data allowed for a rapid and efficient way to search for molecular outflows over a large (~ 16 sq. deg.) area. Our outflow-searching technique detected previously known molecular outflows as well as new candidate outflows. Most of these new outflow-related high-velocity features lie in regions that have been poorly studied before. These new outflow candidates more than double the amount of outflow mass, momentum, and kinetic energy in the Perseus cloud complex. Our results indicate that outflows have significant impact on the environment immediately surrounding localized regions of active star formation, but lack the energy needed to feed the observed turbulence in the entire Perseus complex. This implies that other energy sources, in addition to protostellar outflows, are responsible for turbulence on a global cloud scale in Perseus. We studied the impact of outflows in six regions with active star formation within Perseus of sizes in the range of 1 to 4 pc. We find that outflows have enough power to maintain the turbulence in these regions and enough momentum to disperse and unbind some mass from them. We found no correlation between outflow strength and star formation efficiency for the six different regions we studied, contrary to results of recent numerical simulations. The low fraction of gas that potentially could be ejected due to outflows suggests that additional mechanisms other than cloud dispersal by outflows are needed to explain low star formation efficiencies in clusters.Comment: Published in The Astrophysical Journa

Brain–computer interface game applications for combined neurofeedback and biofeedback treatment for children on the autism spectrum

Individuals with Autism Spectrum Disorder (ASD) show deficits in social and communicative skills, including imitation, empathy, and shared attention, as well as restricted interests and repetitive patterns of behaviors. Evidence for and against the idea that dysfunctions in the mirror neuron system are involved in imitation and could be one underlying cause for ASD is discussed in this review. Neurofeedback interventions have reduced symptoms in children with ASD by self-regulation of brain rhythms. However, cortical deficiencies are not the only cause of these symptoms. Peripheral physiological activity, such as the heart rate, is closely linked to neurophysiological signals and associated with social engagement. Therefore, a combined approach targeting the interplay between brain, body and behavior could be more effective. Brain-computer interface applications for combined neurofeedback and biofeedback treatment for children with ASD are currently nonexistent. To facilitate their use, we have designed an innovative game that includes social interactions and provides neural- and body-based feedback that corresponds directly to the underlying significance of the trained signals as well as to the behavior that is reinforced

CO Isotopologues in the Perseus Molecular Cloud Complex: the X-Factor and Regional Variations

We use the COMPLETE data to derive new calibrations of the X-factor and the 13CO abundance within Perseus. We divide Perseus into six sub-regions. The standard X factor, X=N(H2)/W(12CO), is derived both for the whole Perseus Complex and for each of the six sub-regions with values consistent with previous estimates. The X factor is heavily affected by the saturation of the emission above AV~4 mag, and variations are found between regions. We derive linear fits to relate W(12CO) and AV using only points below 4 mag of extinction, this yields a better estimation of the AV than the X-factor. We derive linear relations of W(13CO), N(13CO) and W(C18O) with AV . The extinction threshold above which 13CO(1-0) and C18O(1-0) are detected is about 1 mag larger than previous estimates. 12CO(1-0) and 13CO(1-0) lines saturate above 4 and 5 mag, respectively, whereas C18O(1-0) never saturates (up to 10 mag). Approximately 60% of the positions with 12CO emission have sub-thermally excited lines, and almost all positions have 12CO excitation temperatures below the dust temperature. Using the Meudon PDR code we find that 12CO and 13CO emission can be explained by uniform slab models with densities ranging between about 10^3 and 10^4 cm-3. Local variations in the volume density and non-thermal motions (linked to different star formation activity) can explain the observations. Higher densities are needed to reproduce CO data toward active star forming sites, where the larger internal motions driven by the young protostars allow more photons from the embedded high density cores to escape the cloud. In the most quiescent region, the 12CO and 13CO emission appears to arise from an almost uniform thin layer of molecular material at densities around 10^4 cm-3.Comment: 40 pages, 12 figures, accepted for publication in ApJ; version with high resolution figures available at http://www.cfa.harvard.edu/~jpineda/post/cal-co-v2.pd

The Perils of Clumpfind: The Mass Spectrum of Sub-structures in Molecular Clouds

We study the mass spectrum of sub-structures in the Perseus Molecular Cloud Complex traced by 13CO (1-0), finding that $dN/dM\propto M^{-2.4}$ for the standard Clumpfind parameters. This result does not agree with the classical $dN/dM\propto M^{-1.6}$. To understand this discrepancy we study the robustness of the mass spectrum derived using the Clumpfind algorithm. Both 2D and 3D Clumpfind versions are tested, using 850 $\mu$m dust emission and 13CO spectral-line observations of Perseus, respectively. The effect of varying threshold is not important, but varying stepsize produces a different effect for 2D and 3D cases. In the 2D case, where emission is relatively isolated (associated with only the densest peaks in the cloud), the mass spectrum variability is negligible compared to the mass function fit uncertainties. In the 3D case, however, where the 13CO emission traces the bulk of the molecular cloud, the number of clumps and the derived mass spectrum are highly correlated with the stepsize used. The distinction between "2D" and "3D" here is more importantly also a distinction between "sparse" and "crowded" emission. In any "crowded" case, Clumpfind should not be used blindly to derive mass functions. Clumpfind's output in the "crowded" case can still offer a statistical description of emission useful in inter-comparisons, but the clump-list should not be treated as a robust region decomposition suitable to generate a physically-meaningful mass function. We conclude that the 13CO mass spectrum depends on the observations resolution, due to the hierarchical structure of MC.Comment: 5 pages, 3 figures. Accepted for publication in ApJ Letter